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李延伟
作者:   时间:2018-02-01   点击数:

李延伟

博士 副教授 博/硕士生导师

通讯地址:山东省青岛市即墨滨海路72号

办公电话:0532-58631990

E-mail:lyw@sdu.edu.cn

2017/09-至今,山东大学,环境研究院,副教授

2015/11-2016/11,加州大学洛杉矶分校,化学与生物化学系,访问学者,合作导师:Kendall Houk教授

2014/07-2017/09,山东大学,环境研究院,助理研究员

教育背景

2009/09-2014/06,山东大学,环境研究院,博士,导师:张庆竹教授

2005/09-2009/06,山东大学,化学与化工学院,学士

学术兼职:

现任职务:

研究方向:

微生物体内关键酶对持久性环境污染物的降解机理研究

典型环境污染物与人体关键大分子(DNA、蛋白质等)的相互作用机理研究

毕业学生:

鲍雷(2016级),去向:中国科学院大学,读博

王小丹(2016级),去向:安徽节源环保科技公司,工作

主持承担的科研项目:

1.山东大学青年学者未来计划,项目编号:2018WLJH54,负责人

2.国家科技重大专项课题(子任务),项目编号:2017ZX07202-002,子任务负责人

3.国家自然科学基金重点项目专项(子课题),项目编号:91644214,子课题负责人

4.国家自然科学基金青年项目,项目编号:21507073,负责人(已结题)

5.山东省自然科学基金培育基金,项目编号:ZR2015PB002,负责人(已结题)

6.山东大学基本科研业务费资助项目,项目编号:2015GN007,负责人(已结题)

7.国家自然科学基金面上项目,项目编号:21577082,参与(已结题)

8.国家自然科学基金面上项目,编号:21177077,参与(已结题)

 代表性论文与著作(#共同第一,*通讯作者):

(1) Yanwei Li*, Yue Yue, Hongxia Zhang, Zhongyue Yang, Hui Wang, Shaixiao Tian, Jian-bo Wang*, Qingzhu Zhang*, Wenxing Wang. Harnessing fluoroacetate dehalogenase for defluorination of fluorocarboxylic acids: in silico and in vitro approach. Environment International, 2019, 131, 104999.

(2) Xiaodan Wang, Jinfeng Chen, Xiaowen Tang, Junjie Wang, Ledong Zhu, Weixin Zhang, Hui Wang, Yanwei Li*, Qingzhu Zhang. Biodegradation mechanism of polyesters by hydrolase from Rhodopseudomonas palustris: An in silico approach. Chemosphere, 2019, 221, 11-20.

(3) Lei Bao, Wen Liu, Yanwei Li*, Xueyu Wang, Fei Xu, Zhongyue Yang, Yue Yue, Chenpeng Zuo, Qingzhu Zhang* and Wenxing Wang, Carcinogenic Metabolic Activation Process of Naphthalene by the Cytochrome P450 Enzyme 1B1: A Computational Study. Chemical Research Toxicololy, 2019, 32, 603-612.

(4) Pijun Duan,  Tengfei Ma,  Yue Yue,  Yanwei Li*,  Xue Zhang,  Yanan Shang,  Baoyu Gao,  Qingzhu Zhang,  Qinyan Yue  and  Xing Xu*.  Fe/Mn nanoparticles encapsulated in nitrogen-doped carbon nanotubes as a peroxymonosulfate activator for acetamiprid degradation. Environmental Science: Nano, 2019, 6, 1799-1811.

(5) Jianxin Guan#, Chuancheng Jia#, Yanwei Li#, Zitong Liu#, Jinying Wang, Zhongyue Yang, Chunhui Gu, Dingkai Su, Kendall N. Houk*, Deqing Zhang*, and Xuefeng Guo*, Direct single-molecule dynamic detection of chemical reactions. Science Advances, 2018, 4, eaar2177. (Highlighted by C&EN)

(6) Zhongyue Yang#, Song Yang#, Peiyuan Yu#, Yanwei Li#, Charles Doubleday, Jiyong Park, Ashay Patel, Byung-sun Jeon, William K. Russell, Hung-wen Liu, David H. Russell, and Kendall N. Houk*, Influence of water and enzyme SpnF on the dynamics and energetics of the ambimodal [6+4]/[4+2] cycloaddition, Proceedings of the National Academy of Sciences of the United States of America, 2018, 115, E848-E855.

(7) Yanwei Li, Xiaodan Wang, Ruiming Zhang, Junjie Wang, Zhongyue Yang, Likai Du*, Xiaowen Tang, Qingzhu Zhang*, Wenxing Wang, Computational Evidence for the Enzymatic Transformation of 2-hydroxypropylphosphonate to Methylphosphonate, ACS Earth and Space Chemistry, 2018, 2, 888894.

(8) Yanwei Li, Ruiming Zhang, Likai Du, Qingzhu Zhang*, Wenxing Wang, Catalytic mechanism of C-F bond cleavage: insights from QM/MM analysis of fluoroacetate dehalogenase, Catalysis Science & Technology, 2016, 6(1): 73-80. (Outside Front Cover)

(9) Yanwei Li, Ruiming Zhang, Likai Du, Qingzhu Zhang*, Wenxing Wang, How Many Conformations of Enzymes Should Be Sampled for DFT/MM Calculations? A Case Study of Fluoroacetate Dehalogenase, International Journal of Molecular Sciences, 2016, 17(8), 1372.

(10) Yanwei Li, Xiangli Shi , Qingzhu Zhang*, Jingtian Hu, Jianmin Chen, and Wenxing Wang, Computational Evidence for the Detoxifying Mechanism of Epsilon Class Glutathione Transferase Toward the Insecticide DDT, Environmental Science & Technology, 2014, 48 (9): 5008-5016.




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